A Fibromyalgia, Chronic Fatigue & Central Sensitivity Syndrome Online Resource
"E'er one acquires what one desires if that one is amenable to await and cultivate for it's transpires."

While many forms of Photo Therapies are being used for psychological conditions and cancer treatments in clinics it is still experimental, and at home Photoreactivation treatment, DNA repair to cure chronic illnesses, is pretty much a good decade away. Today many use Photo Therapy though most just go outside more often for UVA exposure and some use UVA light bulbs in the home with an exposure limit, but these methods are mainly for psychological conditions only.

Central Sensitivity Syndrome

My condition is cause by congenital exposure to a concentrated dosage of Dioxin. Dioxin is a mutagen in which it mutates DNA in my case causing severe sensitivity issues with all aspects of my body and mind. This therapy has not been used for this condition before. This was not a treatment my doctor prescribed for me. It is a therapy I feel through extensive research in the area could work to in the manner described below.

Mutation, Mutagens, and DNA Repair Through Photoreactivation

This is one of the simplest and perhaps oldest repair systems: it consists of a single enzyme which can split pyrimidine dimers (break the covalent bond) in presence of light.

Our cell's DNA is continuously replicated in order to grow, maintain and repair tissues within our bodies. Although this process is repeated many millions of times daily, the rate of error of replication of our genetic material is surprisingly low. So how is this possible? As humans have evolved into increasingly complex organisms, biological repair mechanisms which mend damaged DNA have made it possible for us to pass on our genetic material to future generations with high accuracy, therefore increasing our chances of survival as a species.

Reactivation

There is potential for cells to repair themselves either in the dark or by exposure to visible and near UV light (photoreactivation). Cells repair themselves in three ways. (1) Photoenzymatic repair in which exposure to wavelengths between 310-480 nm (near UV – visible) provides the energy for an enzyme to split the pyrimidine dimer; (2) excision-resynthesis, in which the UV photoproduct is excised and replaced; and (3) postreplication repair, in which uninjured portions of either multiple replicate DNA strands or the two complement DNA strands are recombined to form the original sequence (Harm 1980, p.76-121).

The Theoretical Treatment

One way to repair damaged DNA is to reverse it directly, consequently regenerating the correct base pair. An example of this is in the repair of a mutagenic photodimer caused by UV light. An enzyme, called photolyase, binds to the photodimer which breaks the bonds in the presence of specific wavelengths of visible light, which restores the initial base pairs. This process is called photoreactivation. The enzyme photolyase is unable to function without visible light, and therefore alternative DNA-repair mechanisms are responsible in the absence of visible light.

So far this similar treatment has only been used in clinical trials and only with acne treatments. This allows the repair of the structure and thus the normal functioning of the fibroblast DNA thus allowing normal functioning and proliferation of these fibroblasts--which produce the proteins such as collagen and elastin and hyaluronic acid and matrix ground substance which cause skin to be firm and elastic and youthful in appearance--thus producing anti-aging or skin rejuvenation effects in the skin as well as improving the structure and healthy function of the skin. So basically I am taking this research and treatment and taking it a few steps further and a few layers deeper.

Methodology

First Method (Canceled): A method, comprising: exposing target cells in a visual pathway to one or more sources of light having at least one dominant emissive wavelength between about 300 nm and about 350 nm; and delivering an energy fluence to the target cells (general) of less than about 10 J/cm.sup.2.

The method of cl.. Wherein the light sources emit a continuous wave starting at 20 min per session per front and back of upper torso.

The method of cl.. Wherein the light source is pulsed 100 times at the end of the ea. 20 min session.

Future Methods (Canceled)

The method of cl.. Comprising a single source of light having a dominant emissive wavelength of from about 400 nm to about 900 nm starting at 20 min per session per front and back of upper torso. The UVA range is wavelengths from 315 to 400 nanometers which will require more then one light source.

The method of cl.. Wherein the light sources emit a continuous wave starting at 35 min per session per front and back of upper torso.

The method of cl.. Wherein the light source is pulsed 100 times at the end of the ea. 35 min session.

Bulb Being Used: UVA blue full spectrum light 15 watt, presumably 350 nanometers.

New Methodology:

While most SAD lights for therapy are at 10,000 lux each at 14 inches away from the light and direct sunlight is 100,000 lux from a standard distance I've decided to switch to outdoor treatments. These treatments will provide more exposure and more intense treatment long term.

The method of cl.. 30+ minute direct exposure per day.

The method of cl.. Use of 150/60 watt bulbs indoor for all lights.

Predicted Reaction

stable mood
decreased pain
improved mobility
improved sleep quality
more energy/stamina

Migraines or a possible carcinogenic reaction to carcinogenic Dioxin effect on DNA resulting in Malignant Melanoma.

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A Fibromyalgia, Chronic Fatigue & Central Sensitivity Syndrome Online Resource "E'er one acquires what one desires if that one is amenable to await and cultivate for it's transpires."

A Fibromyalgia, Chronic Fatigue & Central Sensitivity Syndrome Online Resource - Copyright 2007

A Fibromyalgia, Chronic Fatigue & Central Sensitivity Syndrome Online Resource
"E'er one acquires what one desires if that one is amenable to await and cultivate for it's transpires."